Mitochondrial Dysfunction and Diabetes: Is Mitochondrial Transfer a Friend or Foe?
Obesity, insulin resistance and type 2 diabetes are accompanied by a variety of systemic and tissue-specific metabolic defects, including inflammation, oxidative and endoplasmic reticulum stress, lipotoxicity, and mitochondrial dysfunction.Over the past 30 years, association studies and genetic manipulations, as well as lifestyle and pharmacologica